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. 2022 Jan 6;29(8-9):1117–1129. doi: 10.1038/s41417-021-00414-5

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© The Author(s) 2021, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A TMEM158 protein expression was detected in a tissue microarray (TMA) (nontumor, n = 2; WHO grade II, n = 12; WHO grade II, n = 12; WHO grade IV, n = 28). B Total IHC staining score of TMA was related to WHO glioma grades, and nontumor samples exhibited the lowest protein expression of TMEM158. C The intratumoral and peritumoral expression patterns of TMEM158. D–G Representative image of TMEM158 expression on nontumor, WHO II, WHO III, and WHO IV tumor samples. H–K Partial enlarged image of (D–G). L RT-PCR results show the expression of TMEM158 mRNA in different grades of gliomas. M Western blotting was used to determine expression of TMEM158 in 8 different glioma cell lines. N Expression of TMEM158 in glioma cell lines in the CCLE database. (^nsp > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).