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. 2022 Jan 6;29(8-9):1117–1129. doi: 10.1038/s41417-021-00414-5

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© The Author(s) 2021, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Volcano plot showing the differentially expressed genes (DEGs) related to TMEM158. We identified a total of 776 upregulated genes and 1040 downregulated genes. B GSEA and HALLMARK gene set enrichment analysis were used to enrich the pathways related to TMEM158-associated genes. C GSEA showed that TMEM158-associated genes were enriched in the EMT process. (NES = 2.89, p < 0.0001). D TMEM158-associated genes were enriched in the STAT3 signaling pathway by GSEA. (NES = 2.20, p < 0.0001) E–F Western blotting results show changes in TMEM158 and EMT marker expression (E-Ca, N-Ca, vimentin, and Snail) in U87MG, U251MG, and TJ905 glioma cells after overexpression and knockdown of TMEM158. G–H TMEM158, STAT3, and p-STAT3 protein levels in U87MG, U251MG, and TJ905 glioma cells after overexpression and knockdown TMEM158 detected by western blotting.