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. 2022 Jan 6;29(8-9):1117–1129. doi: 10.1038/s41417-021-00414-5

Fig. 5. TMEM158 mediates the proliferation, migration, and invasion of glioma cells by activating STAT3 signaling.

Fig. 5

A–C CCK-8 results showing the proliferation of sh-NC + pcDNA, sh-NC + STAT3 pcDNA, sh-TMEM158 + pcDNA, and sh-TMEM158 + STAT3 pcDNA in the four groups of glioma cells. D Colony-formation assay results showing the colony formation efficiency of glioma cells after silencing TMEM158 and upregulating STAT3. E–F Transwell assay results showing that overexpression of STAT3 rescued the reduced migration and invasion caused by TMEM158 knockdown. G Western blotting results showing the expression of TMEM158, STAT3, p-STAT3, E-Ca, N-Ca, vimentin, and Snail in the four groups of glioma cells. (nsp > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).