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. 2022 Aug 23;35(3):101377. doi: 10.1016/j.beha.2022.101377

Fig. 1.

Fig. 1

Formation of CAC in COVID-19 patients. SARS-CoV-2 infection will cause neutrophil activation and NET release, resulting in pathological prothrombotic environment. Pro-inflammatory cytokines can activate neutrophils and endothelial cells, which will further stimulate thrombosis. SARS-CoV-2 might be able to interact with platelets directly, leading to platelet activation and thrombosis. SARS-CoV-2 binding to ACE2 on endothelial cells causes endotheliitis, shifting the vascular equilibrium towards a procoagulant state.