Fig. 3.

Boswellia extract attenuates rotenone-induced dopaminergic neurodegeneration. Animals received treatment with Boswellia extract (500 mg/kg/day/oral) for 2 weeks and then injection of rotenone (4 mg/kg/day, i.p) along with treatment of Boswellia extract for additional 2 weeks. Immunostainings for TH were performed to visualize the dopaminergic neurons in the substantia nigra and the TH-positive fibers in the striatum. a The results show Boswellia extract spares the dopaminergic neurons from rotenone-caused neuronal loss and b deletion of TH-positive fibers. c Stereological counts of TH-positive neurons in the substantia nigra. d Quantification of TH-positive fiber density in the striatum. ns = P > 0.05, **P ≤ 0.01, ***P ≤ 0.001, and ****P ≤ 0.0001. All values represent mean ± SEM (n = 7). Scale bars: 150 μm (4 ×) and 25 μm (20 ×)