Fig. 6.

Boswellia extract attenuates rotenone-induced microglial activation. At 14 days after rotenone administration, mice were euthanized and immunohistochemical analysis for Iba-1, a marker for microglia, were performed to examine change of their phenotype. Immunohistochemical staining showed that clear rotenone-induced activation of microglia in the substantia nigra (a) and mild activation in the striatum (b), which was attenuated by Boswellia extract. Quantification of density of Iba-1 stainings in the substantia nigra (c) and the striatum (d). ns = P > 0.05, ***P ≤ 0.001, ****P ≤ 0.0001. All values represent mean ± SEM (n = 7). Scale bars: 150 μm (4 ×); 50 μm (20 ×) and 12.3 μm (40 ×)