Table 1.
Baseline study populationa characteristics according to quartile of MMP7
| Quartile of MMP7, pg/mL (IQR) |
P-value linear trend | ||||
|---|---|---|---|---|---|
| Characteristics | Quartile 1 (n = 322) | Quartile 2 (n = 322) | Quartile 3 (n = 322) | Quartile 4 (n = 323) | |
| (49–1436) | (1437–1900) | (1901–2347) | (2348–7463) | ||
| Sex (men) [n (%)] | 161 (50) | 168 (52) | 148 (46) | 165 (51) | 0.43 |
| Age (years) | 57.2 (53.5–61.0) | 58.0 (54.3–61.1) | 58.6 (55.0–61.3) | 60.5 (56.0–61.9) | <0.001 |
| Height (cm) | 171.0 (8.9) | 171.2 (8.5) | 170.4 (8.7) | 170.6 (8.3) | 0.22 |
| Weight (kg) | 78.3 (12.6) | 81.1 (13.9) | 79.0 (14.4) | 79.8 (14.5) | 0.84 |
| BMI (kg/m2) | 26.7 (3.4) | 27.6 (4.0) | 27.1 (4.0) | 27.3 (4.0) | 0.29 |
| mGFRiohexol (mL/min/1.73 m2) | 95.7 (13.2) | 95.7 (13.6) | 92.8 (14.2) | 91.1 (15.6) | <0.001 |
| eGFRcre | 97.1 (90.5–101.6) | 97.4 (92.0–101.4) | 96.9 (90.0–100.6) | 95.6 (87.1–100.5) | <0.001 |
| eGFRcys | 108.6 (10.5) | 107.3 (11.7) | 105.0 (11.3) | 102.0 (13.5) | <0.001 |
| eGFRcrecys | 105.4 (10.3) | 104.6 (10.5) | 102.6 (10.3) | 100.0 (12.6) | <0.001 |
| Urinary ACR (mg/mmol) | 0.20 (0.1–0.46) | 0.1 (0.1–0.37) | 0.27 (0.1–0.62) | 0.31 (0.1–0.66) | <0.001 |
| sBP (mmHg) | 125 (114–138) | 126 (116–138) | 129 (118–143) | 131 (119–142) | <0.001 |
| dBP (mmHg) | 82 (9) | 83 (9) | 83 (10) | 85 (10) | <0.001 |
| Antihypertensive medication [n (%)] | 38 (12) | 37 (11) | 48 (15) | 105 (33) | <0.001 |
| RAS inhibitors | 16 (5) | 25 (8) | 30 (9) | 61 (19) | <0.001 |
| Fasting blood glucose (mmol/L) | 5.3 (0.5) | 5.4 (0.5) | 5.4 (0.6) | 5.3 (0.5) | 0.83 |
| LDL cholesterol (mmol/L) | 3.6 (0.8) | 3.7 (0.9) | 3.7 (0.9) | 3.7 (0.8) | 0.08 |
| HDL cholesterol (mmol/L) | 1.6 (0.4) | 1.5 (0.4) | 1.5 (0.4) | 1.5 (0.4) | 0.39 |
| Triglycerides (mmol/L) | 1.0 (0.7–1.4) | 1.0 (0.7–1.4) | 1.0 (0.8–1.5) | 1.1 (0.8–1.5) | 0.03 |
| CRP (mg/L) | 1.02 (0.6–1.8) | 1.21 (0.66–2.13) | 1.17 (0.63–2.28) | 1.3 (0.72–2.8) | <0.001 |
| Daily smoker [n (%)] | 203 (63) | 216 (67) | 216 (67) | 236 (73) | <0.001 |
| Yes, currently | 45 (14) | 51 (16) | 59 (18) | 95 (29) | <0.001 |
| Yes, previously | 158 (49) | 165 (51) | 157 (49) | 141 (44) | 0.12 |
| Never | 119 (37) | 106 (33) | 106 (33) | 87 (27) | <0.001 |
| MMP7 (pg/mL) | 1192 (918–1345) | 1684 (1561–1805) | 2113 (1992–2233) | 2773 (2519–3186) | <0.001 |
| MMP2 (ng/mL) | 311.7 (49.8) | 309.8 (52.8) | 316.5 (51.7) | 323.7 (76.9) | 0.017 |
| TIMP1 (ng/mL) | 156.8 (24.0) | 160.7 (37.7) | 163.3 (25.4) | 166.3 (26.0) | <0.001 |
The data are presented as the means (SD) and median (IQR) for continuous variables, and proportions (%) for dichotomous variables.
a
Study population N = 1302, with 13 missing for MMP7 (N = 1289 for MMP7 analyses).
mGFRiohexol, mGFR with iohexol; RAS, renin–angiotensin system; LDL, low-density lipoprotein.