Fig. 7. Group differences of the positive and negative PRS-associated networks between SZ and HC, between ASD and HC, between MDD and HC, between ADHD and HC.

The identified PRS-associated features appear to be specific to SZ. ASD autism spectrum disorder, MDD major depressive disorder, ADHD attention-deficit/hyperactivity disorder. Two-tailed two-sample T test was used to calculate the group differences between patients and controls in Fig. 7.