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. 2022 Aug 22;13:4923. doi: 10.1038/s41467-022-32275-3

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — 118 loci-metabolite associations are for known metabolites. 401 associations are for unknown metabolite features. The most common metabolite class includes amino acids, peptides, and analogs. Highlighted are sentinel genes with ≧4 locus-metabolite associations.