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. 2022 Aug 22;13:4923. doi: 10.1038/s41467-022-32275-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Association of V122I in TTR with an unknown metabolite (QI722; m/z 269.226); B Correlation between QI722 and retinol-binding protein; C Association of rs769455 missense variant in APOE with unknown metabolite (QI176; m/z 269.226); D TTR associated unknown metabolite matching spectra with trans-retinol; APOE associated unknown metabolite with identical molecular mass but earlier retention time indicating it’s a cis-isomer of retinol. Additional isomers tested without compound match include 9 and 11-cis retinol.