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. 2022 Jun 10;181(9):3459–3471. doi: 10.1007/s00431-022-04516-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a and b-diversity indices of the gut microbiota in fecal samples from the CXM-treated group (F-CXM, n = 13) and CXM-treated group at the follow-up visits (F-CXM-FV, n = 5). A Observed OTUs in the gut microbiota in fecal samples; B cloud plot of the Chao1 estimator regarding the gut microbial community richness in fecal samples; C cloud plot of the Shannon index regarding the gut microbial community diversity in fecal samples; D multiple-samples PCoA analysis regarding the difference in the microbial community composition in fecal samples. Blue circles represent samples of the F-CXM group; yellow squares represent samples of the F-CXM-FV group. Each box plot represents the median, interquartile range, minimum, and maximum values. *The data are statistically significantly different from the F-CXM group (p < 0.05)