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. 2022 Jul 8;59(9):5856–5873. doi: 10.1007/s12035-022-02945-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — DHCR24 downregulation reduced cholesterol esterification and total cholesterol content in C8D1A astrocytes. a Transcription level of ACAT was measured by qPCR analysis. The values are shown as the means ± SEM, n = 3 per group. b Representative images of Oil Red O staining of lipid droplets of astrocytes from blank control group (Blank, BL) and vector groups (Negative control, NC1 or NC2), DHCR24 low expression (LE) and overexpression (OE) groups. Magnification: 60 × , Scale bar: 20 µm. The images were captured at random, and the average number of lipid droplets from each group was analyzed using Image Pro Plus 6.0 version. One-way ANOVA analysis of the results was shown at (c). d Quantification of total cholesterol content. One-way ANOVA analysis, *P < 0.05; **P < 0.01; compared with control groups (BL, NC1 and NC2)