TABLE 1.
Uric acid–lowering effects of traditional Chinese herbs.
| Traditional Chinese herb | Animal model | UA-lowering targets | Reference |
|---|---|---|---|
| Smilax glabra (Tu-Fu-Ling) | HN mice | XOR, GLUT9, and OAT1 | (Chen et al., 2011; Li et al., 2017; Shi et al., 2018; Yan et al., 2018) |
| HN rats | |||
| Smilax china L. (Ba-Qia, Jin-Gang-Teng) | HN mice | XOR | Meng et al. (2017) |
| Mesona procumbens Hemsl. (Xian-Cao) | diabetic rats | XOR, GLUT9, and OAT1 | Chen et al. (2020) |
| HN mice | |||
| Scutellariae radix (Huang-Cen) | HN mice | XOR | (Dong et al., 2017; Bao et al., 2018; Hua et al., 2018) |
| Morus alba L. (Sang-Shu) | HN mice | XOR, URAT1, GLUT9, and OAT1 | (Yang et al., 2008a; Yang et al., 2008b; Chan et al., 2016; Jhang et al., 2016; Phimarn et al., 2017; Yeh et al., 2019) |
| Rhododendron oldhamii Maxim. (Zhuan-Hong-Du-Juan) | HN mice | Unclear | Hunyadi et al. (2013) |
| Chrysanthemum morifolium Ramat. (Ju-Hua) | HN rats | XOR, ABCG2, URAT1, and GLUT9 | Caselli et al. (2016) |
| Liriodendron chinense (Hemsl.) Sarg (E-Zhang-Qiu) | HN mice | OAT1, OAT3, and ABCG2 | Sun et al. (2015) |
| Fructus Gardenia (Zhi-Zi) | HN mice | XOR, URAT1, GLUT9, OAT1, and OAT3 | (Peng et al., 2019; Liu et al., 2020) |
| Poria cocos (Fu-Ling) | HN mice | ABCG2 | Liu et al. (2017) |
| Dendrobium officinalis six nostrum (Tie-Pi-Shi-Hu) | HN rats | ABCG2 and GLUT9 | Tung et al. (2015) |
HN, hyperuricemic nephropathy; XOR, xanthine oxidoreductase; GLUT9, glucose transporter 9; OAT1, organic anion transporter 1; ABCG2, ATP-binding cassette superfamily G member 2; URAT1, urate anion transporter 1; OAT3, organic anion transporter 3.