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. 2022 Aug 9;10:950837. doi: 10.3389/fcell.2022.950837

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Copyright © 2022 Paciello, Zorzi, Raspa, Scavizzi, Grassi, Mammano and Fetoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cx26 expression in Cx30 ΔΔ-aging cochleae. (A) Representative western blot immunoreactive bands showing the expression of Cx26 in cochlear lysates from Cx30 WT and Cx30 ΔΔ animals at 12 months of age. (B) Histograms (mean ± S.E.M.) represent optical density values normalized to α-tubulin. N = 8 cochleae/group. (C–F) Immunofluorescence analysis for Cx26 expression in Cx30 WT and Cx30 ΔΔ organ of Corti (C and D) and stria vascularis and spiral ligament (E and F) from 12 months of age cochleae. IHC: inner hair cell; OHCs: outer hair cells; OS: outer sulcus; IC: inner sulcus; StV: stria vascularis; and SL: spiral ligament. Scale bar: 50 μm. N = 4 cochleae/group. Experiments were performed in triplicate. Asterisks indicate significant differences between groups from Student’s t-test (*p < 0.05).