Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 9;10:950837. doi: 10.3389/fcell.2022.950837

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Paciello, Zorzi, Raspa, Scavizzi, Grassi, Mammano and Fetoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Increased oxidative stress and inflammation in the cochlea of Cx30 ΔΔ mice of 12 months of age. (A and B): Representative images of cochlear cryosections from Cx30 WT (A) and Cx30 ΔΔ (B) mice of 12 months of age stained with DHE to analyze the ROS amount. N = 4 cochleae/group. High magnifications of spiral ganglion neurons (a1 and b1), the organ of Corti (a2 and b2), and stria vascularis (a3 and b3) are shown. (C): Representative western blot immunoreactive bands quantifying the expression of NF-κB in cochlear lysates from Cx30 WT and Cx30 ΔΔ animals at 12 months of age. (D) Histograms (mean ± S.E.M.) represent optical density normalized to GAPDH. N = 8 cochleae/group. Asterisks indicate significant differences between groups from Student’s t-test (*p < 0.05). SGNs, spiral ganglion neurons; oC, organ of Corti; StV, stria vascularis.