ADCC |
Antibody-dependent Cellular Cytotoxicity |
AEs |
Any-Grade Adverse Events |
ALL |
Acute Lymphoblastic Leukemia |
AML |
Acute Myeloid Leukemia |
AP1 |
Activator Protein 1 |
APCs |
Antigen-presenting Cells |
ASCT |
Autologous Stem Cell Transplantation |
B-ALL |
B-cell acute lymphoblastic lymphoma |
BCMA |
B-Cell Maturation Antigen |
BM |
Bone Marrow |
CAR |
Chimeric Antigen Receptors |
cilta-cel |
Ciltacabtagene Autoleucel |
CI |
Confidence Interval |
CRS |
Cytokine Release Syndrome |
DLBCL |
Diffuse Large B-Cell Lymphoma |
FDA |
Food and Drug Administration |
FKBP |
FK506 Binding Protein |
GBM |
glioblastoma multiforme
|
GPRC5D |
G-Protein Coupled Receptor Family C Group 5 Member D |
iCasp9 |
inducible Caspase 9 |
ide-cel |
Idecabtagene Vicleucel |
IMiD |
Immunomodulatory Drugs |
iCARs |
Inhibitory CARs |
IFN-γ |
Interferon Gamma |
IL |
Interleukin |
IMWG |
International Myeloma Working Group |
LAG3 |
Lymphocyte Activating 3 |
MM |
Multiple Myeloma |
MRD |
Measurable Residual Disease |
NF-κB |
Nuclear Factor Kappa-B |
ORR |
Overall Response Rate |
OS |
Overall Survival |
PC |
Plasma Cell |
PD-1 |
Programmed Cell Death Protein 1 |
PFS |
Progression-Free Survival |
PI |
Proteasome Inhibitors |
RRMM |
Relapsed and/or Refractory Multiple Myeloma |
SEMA4A |
Semaphorin-4A |
SLAMF7 |
Signaling Lymphocyte Activation Molecule F7 |
scFv |
Single-Chain Variable Fragment |
sBCMA |
Soluble B-Cell Maturation Antigen |
sCR |
Stringent Complete Response |
STAT5 |
Signal Transducer and Activator of Transcription 5 |
TCR |
T-cell Receptor |
TRUCK |
T-cells Redirected for Universal Cytokine Killing |
TGF-β |
Transforming Growth Factor-beta |
TME |
Tumor Microenvironment |
TNF-α |
Tumor Necrosis Factor-Alpha |
VGPR |
Very Good Partial Response |