Table 1.

The roles of conventional Th2 cells and Tpath2 cells in inflammation, tissue repair, and fibrosis.

Cell type	Situation	Role	Reference
Conventional Th2 cells	Inflammation	Exacerbation of airway inflammation Exacerbation of atopic dermatitis Exacerbation of eosinophilic esophagitis Exacerbation of inflammation against parasites infection Exacerbation of inflammation against Aspergillus fumigatus	(37) (38) (40) (56) (72) (74) (53) (55) (65) (44) (45) (119) (13)
	Tissue repair	Induction of the tissue repair response of macrophage Induction of the hepatocyte proliferation by secreting IL-4 Activation of myofibroblasts by IL-13	(7) (94) (97) (8)
	Fibrosis	Exacerbation of skin fibrosis Exacerbation of lung fibrosis Exacerbation of lung fibrosis by increasing MMP12 via IL-13 Exacerbation of skin fibrosis by activating macrophage	(84) (125) (118) (13) (185) (119) (120)
Tpath2 cells	Inflammation	Exacerbation of airway inflammation Exacerbation of atopic dermatitis Exacerbation of eosinophilic esophagitis	(39) (56) (66) (70) (52) (55) (63) (53) (65)
	Fibrosis	Exacerbation of lung fibrosis via eosinophil	(12)