Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 9;10:861609. doi: 10.3389/fchem.2022.861609

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Sandalova, Sala and Achour.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The myristoyl moiety in myristoylated peptides plays an essential role in both MHC-I binding and adequate presentation of the epitope (A). The crystal structure of the rhesus macaque MHC-I molecule Mamu-B*098 in complex with the myristoylated 5-mer lipopeptide derived from SIV Nef protein (4ZFZ.pdb), reveals the dual role of the PTM moiety in both adequate binding to the MHC-I and peptide presentation (Morita and Sugita 2016). (B). The crystal structure of the rhesus macaque MHC-I molecule Mamu-B*05,104 in complex with a N-myristoylated 4-mer lipopeptide derived from the SIV nef protein (6IWG.pdb) shows how the myristoyl moiety occupies the cleft differently (Yamamoto et al., 2019)