TABLE 1.
Identification of ions and their alteration trend in positive and negative mode.
| No | tR (min) | m/z | Formula | Identification | Fragments | Change trend# | Pathway | |
| Control# | Hawthorn# | |||||||
| 1 | 6.56 | 691.5278 | C45H70O5 | DG (22:6/20:3/0:0) | M + H | ↓ | ↓ | Glycerolipids |
| 2 | 6.72 | 697.4424 | C41H65O8P | PA (18:4/20:4) | M-H20-H | ↑ | ↑ | Glycerophospholipids |
| 3 | 9.52 | 678.6843 | C44H87NO3 | Cer(18:1/26:0) | M + H | ↓ | ↓ | Sphingolipids |
| 4 | 11.81 | 937.5278 | C49H81N2O11 PS | PC(18:4) | M + H | ↓ | ↓ | Glycerophospholipids |
| 5 | 11.89 | 863.5125 | C44H82O13P2 | PGP (20:1/18:2) | M + H-H2O | ↓ | ↓ | Glycerophospholipids |
| 6 | 12.21 | 889.5266 | C45H81N2O11 PS | PC(14:0) | M + H | ↓ | ↓ | NC |
| 7 | 12.35 | 699.5023 | C39H73O9P | PA (18:0/18:1) | M + H-H2O | ↓ | ↓ | NC |
| 8 | 12.36 | 698.4993 | C39H72NO7P | PE (16:0/18:3) | M + H | ↓ | ↓ | Glycerophospholipids |
| 9 | 12.49 | 728.5277 | C40H76NO9P | PE (18:3/16:0) | M + H-H2O | ↓ | ↓ | Glycerophospholipids |
| 10 | 12.83 | 939.5446 | C49H83N2O11 PS | PC(18:3) | M + H | ↓ | ↓ | NC |
| 11 | 12.99 | 816.5313 | C46H78NO10P | PS(20:3/20:3) | M-H20-H | ↓ | ↓ | Glycerophospholipids |
| 12 | 13.19 | 794.5302 | C44H80NO10P | PS(20:2/18:1) | M-H20-H | ↓ | ↓ | Glycerophospholipids |
| 13 | 13.57 | 784.5012 | C42H76NO10P | PS(20:3/16:0) | M-H | ↓ | ↓ | Glycerophospholipids |
| 14 | 14.13 | 770.5297 | C42H80NO10P | PS(18:1/18:0) | M-H20-H | ↓ | ↓ | Glycerophospholipids |
| 15 | 14.31 | 868.5643 | C50H82NO10P | PS(22:6/22:2) | M-H20-H | ↓ | ↓ | Glycerophospholipids |
| 16 | 14.36 | 794.5477 | C44H80NO10P | PS(20:3/18:0) | M-H20-H | ↑ | ↑ | Glycerophospholipids |
| 17 | 14.78 | 859.5980 | C47H87O11P | PA (24:0) | M + H | ↓ | ↓ | NC |
| 18 | 15.91 | 808.5985 | C46H84NO8P | PE-NMe(22:4/18:0) | M-H | ↑ | ↑ | Glycerophospholipids |
| 19 | 16.05 | 676.4808 | C36H72NO8P | PE (16:0/15:0) | M-H | ↑ | ↑ | Glycerophospholipids |
| 20 | 16.09 | 902.6041 | C46H80O13P2 | PGP (22:6/18:0) | M-H | ↑ | ↑ | Glycerophospholipids |
| 21 | 17.61 | 849.6478 | C57H88O6 | TG (20:5/14:1/20:5) | M-H20-H | ↑ | ↑ | Glycerolipids |
| 22 | 17.68 | 823.6308 | C55H86O6 | TG (14:1/20:5/18:4) | M-H20-H | ↑ | ↑ | Glycerolipids |
| 23 | 18.25 | 735.5132 | C39H75O10P | PA (18:1/18:0) | M + H | ↓ | ↓ | NC |
| 24 | 18.34 | 629.5506 | C41H76O5 | DG (18:1/0:0/20:1) | M-H20-H | ↑ | ↑ | Glycerolipids |
| 25 | 18.58 | 836.6542 | C49H94NO8P | PE-NMe2 (18:1/24:1) | M-H20-H | ↑ | ↑ | Glycerophospholipids |
| 26 | 19.46 | 927.6815 | C63H94O6 | TG (18:4/22:5/20:5) | M-H20-H | ↑ | ↑ | Glycerolipids |
| 27 | 19.47 | 853.6671 | C57H92O6 | TG (14:0/20:5/20:4) | M-H20-H | ↑ | ↑ | Glycerolipids |
| 28 | 20.06 | 873.7097 | C57H94O6 | TG (14:0/20:4/20:4) | M-H | ↓ | ↓ | Glycerolipids |
| 29 | 22.84 | 839.5599 | C47H83O10P | PA (i-24:0) | M + H | ↑ | ↑ | NC |
| 30 | 23.99 | 625.5183 | C41H70O5 | DG (38:5) | M + H-H2O | ↓ | ↓ | Glycerolipids |
| 31 | 24.29 | 901.5058 | C46H80O13P2 | PGP (18:1/22:5) | M-H | ↓ | ↓ | Glycerophospholipids |
Model#: Trends of the model group compared with the control group of metabolites. Hawthorn#: Trends of the treatment group compared with the model group of metabolites. NC: not classified.