Fig. 1.

Effects of simvastatin on biofilm inhibition and disruption.

A-DS. aureus and S. epidermis were treated with simvastatin at different concentrations for 24 h. The inhibition effect and disruption effect were measured by crystal violet staining. Data are shown as the mean ± SD, n = 3, * for P < 0.05, ** for P < 0.01, *** for P < 0.001. E-H Confocal fluorescence images showed S. aureus and S. epidermis biofilms after 24 h of treatment with simvastatin at different concentrations. Live cells were stained green and dead cells were stained red. Scale bar: 20 μm.