Table 3.
Outcomes of the 11 RCTs
| Author-year | Intervention | Death, n/total | Major bleeding, n/total | Ventilator-free days, median (IQR) | Major thrombotic events, n (%) | Any bleeding, n (%) | VTE, n (%) | Any thrombotic events, n (%) | Venous thromboembolism | Arterial thromboembolism |
|---|---|---|---|---|---|---|---|---|---|---|
| Spyropoulos-2021 [21] | TA | 25/129 | 6/129 | / | / | / | / | / | 12/129 | 4/129 |
| PA | 31/124 | 2/124 | / | / | / | / | / | 33/124 | 4/124 | |
| Lemos-2020 [13] | TA | 2/10 | 0/10 | 0 (0–11) | 2 (20) | 2 (20) | / | / | 2/10 | 0/10 |
| PA | 5/10 | 0/10 | 15 (6–16) | 2 (20) | 0 (0) | / | / | 2/10 | 0/10 | |
| Goligher-2021 [12] | TA | 199/534 | 20/529 | / | 34 (6.4) | / | / | 38 (7.2) | 19/530 | 23/530 |
| PA | 200/564 | 13/562 | / | 58 (10.4) | / | / | 62 (11.1) | 48/559 | 22/559 | |
| Lawler-2021 [22] | TA | 86/1180 | 22/1180 | / | 13 (1.1) | / | / | / | 16/1180 | 3/1180 |
| PA | 86/1046 | 9/1047 | / | 22 (2.1) | / | / | / | 26/1046 | 5/1046 | |
| Connors-2021 [26] | TA | 0/164 | / | / | / | 13 (9.1) | / | / | 0/164 | 0/164 |
| PA | 0/165 | / | / | / | 9 (6.7) | / | / | 0/165 | 0/165 | |
| Marcos-Jubilar-2021 [23] | TA | 2/32 | 0/32 | / | 0 | / | / | / | 0/32 | 0/32 |
| PA | 1/33 | 0/33 | / | 2 (6.1) | / | / | / | 2/33 | 0/33 | |
| Sholzberg-2021 [24] | TA | 4/228 | 2/228 | / | / | / | 2 (0.9) | / | 2/228 | 0/228 |
| PA | 18/237 | 4/237 | / | / | / | 6 (2.5) | / | 6/237 | 1/237 | |
| Morici-2021 [25] | TA | 5/91 | 1/91 | / | / | 0 | 0 | / | 0/91 | 0/91 |
| PA | 1/92 | 1/92 | / | / | 0 | 6 (6.5) | / | 6/92 | 2/92 | |
| Sadeghipour-2021 [27] | TA | 119/276 | 7/276 | 30 (3–30) | / | 17 (6.2) | 9 (3.3) | / | 9/276 | 1/276 |
| PA | 117/286 | 4/286 | 30 (1–30) | / | 9 (3.1) | 10 (3.5) | / | 10/286 | 1/286 | |
| Lopes-2021 [14] | TA | 35/311 | 10/311 | / | 23 (7) | 36 (12) | 11 (4) | / | 11/310 | 14/310/ |
| PA | 23/304 | 4/304 | / | 30 (10) | 9 (3) | 18 (6) | / | 18/304 | 15/304 | |
| Perepu-2021 [11] | TA | 13/87 | 2/87 | / | / | 8 (9) | 7 (8) | / | 7/87 | 5/87 |
| PA | 18/86 | 2/86 | / | / | 8 (9) | 6 (7) | / | 6/86 | 3/86 |
Abbreviations: VTE Venous thromboembolism, IQR Interquartile range, TA Therapeutic anticoagulation, PA Prophylactic anticoagulation