TABLE 3.
Top canonical pathways as predicted targets for aging-induced miRNAs content changes in circulating adipocyte-derived EVPs from aged animals compared to young adult (−log (p-value) ≥3; z-score ≥2 or ≤−2).
| Ingenuity Canonical Pathways | −log(p-value) | z-score |
|---|---|---|
| Molecular Mechanisms of Cancer | 10.1 | #NÚM! |
| Glioblastoma Multiforme Signaling | 9.5 | −2.611 |
| Glioma Signaling | 8.14 | −3.13 |
| Cardiac Hypertrophy Signaling (Enhanced) | 8 | −5.658 |
| Pancreatic Adenocarcinoma Signaling | 7.63 | −3.838 |
| Estrogen-mediated S-phase Entry | 7.34 | −2.496 |
| Ovarian Cancer Signaling | 7.26 | −3.153 |
| PTEN Signaling | 7.24 | 3.528 |
| GADD45 Signaling | 7.15 | #NÚM! |
| PI3K/AKT Signaling | 6.75 | −2.887 |
| Role of Osteoblasts. Osteoclasts and Chondrocytes in Rheumatoid Arthritis | 6.61 | #NÚM! |