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. 2022 Aug 9;12:963928. doi: 10.3389/fonc.2022.963928

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Copyright © 2022 Huo, Shen, Zhang and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BI 2536 induces GSDME-dependent pyroptosis of ovarian cancer cells (A) Representative images of A2780 cells treated with DMSO and BI 2536 for 72 hours. Pyroptotic cell morphology is pinpointed by arrows. (B) LDH and (C) HMGB1 release from A2780 cells treated with BI 2536. Each column represents the mean value of three biological replicates, and error bars indicate SD. (D, E) Immunoblotting analysis of the indicated proteins extracted from BI 2536-treated cells. Scale bar = 200μm. ***P < 0.001.