TABLE 2.

Core ingredients, targets and pathways of CASR against CHD.

Categories	No.	Name	Degree	Closeness centrality	Betweenness centrality
Ingredients	1	β-Elemene	17	0.4407	1158.1643
	2	Curzerene	13	0.4041	477.4343
	3	Demethoxycurcumin	10	0.3768	721.6091
	4	Curzerenone	9	0.3697	430.3524
	5	Isoprocurcumenol	9	0.3498	267.5783
	6	Furanodiene	8	0.3768	199.6757
	7	(+)-Curcumenol	7	0.3498	474.8281
	8	(+)-Limonene	6	0.3805	159.5248
Targets	1	CHRM1	12	0.4239	449.3520
	2	GABRA1	12	0.4382	877.9484
	3	PTGS2	11	0.4021	484.3543
	4	CHRM2	10	0.4021	322.9952
	5	PRKACA	9	0.3939	461.0935
	6	CHRM3	8	0.3900	203.9512
	7	PTGS1	8	0.3786	272.0650
	8	NOS3	7	0.3679	217.8825
	9	ADRB2	6	0.3714	228.0657
	10	F2	6	0.3611	144.2236
	11	NR3C1	5	0.3391	255.5735
	12	BCL2	5	0.3451	102.1192
	13	NCOA2	5	0.3514	162.6703
	14	RXRA	5	0.3545	171.7665
	15	ADRA1B	4	0.3421	37.9374
	16	ADRA1A	4	0.3645	55.2813
	17	HTR2A	4	0.3421	51.9311
	18	HSP90AA1	4	0.3333	101.4216
	19	PGR	4	0.3223	70.3906
	20	SLC6A2	4	0.3482	48.3808
	21	RHOA	3	0.3223	33.3751
Pathways	1	Neuroactive ligand-receptor interaction	15	0.4171	769.3469
	2	Calcium signaling pathway	11	0.3959	349.4705
	3	Estrogen signaling pathway	9	0.3732	474.9934
	4	PI3K-Akt signaling pathway	8	0.3732	199.6417
	5	Cholinergic synapse	6	0.3697	132.2672