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. 2022 Jul 14;298(8):102264. doi: 10.1016/j.jbc.2022.102264

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Docking suggests key PI(4,5)P₂phosphate interactions with TMEM16A. Docking was performed with either diC8-PI(4,5)P₂ or IP₃ into a homology model of Xenopus laevis TMEM16A (xTMEM16A). A, position of diC8-PI(4,5)P₂ shown against the homology model of xTMEM16A. Lines indicating the position of the intracellular and extracellular boundaries of the plasma membrane were created using the OPM entry for mouse TMEM16A (PDB: 5OYB). B, detailed view of the hypothesized PI(4,5)P₂–xTMEM16A interaction. Interacting residues (E442, K446, R450, K592, and K912 from the other chain) and phosphates (positions 2′–5′) are highlighted. C, superposition of docked IP₃ (foreground) on the PI(4,5)P₂–xTMEM16A (transparency) interaction. diC8-PI(4,5)P₂, dioctanoyl phosphatidylinositol 4,5-bisphosphate; PDB, Protein Data Bank; PI(4,5)P_2, dioctanoyl phosphatidylinositol 4,5-bisphosphate; TMEM16A, TransMEMbrane 16A; xTMEM16A, Xenopus laevis TransMEMbrane 16A.