Functional annotations of differential human oocyte proteins during in vivo maturation.A-C, heatmap and GO annotations of cell cycle proteins (A), transcriptional factors and cofactors (B), as well as epigenetic factors (C). D, network of in vivo differential proteins and mouse reproductive and embryonic phenotypes. The color key ranging from blue to red identifies protein fold changes (IVO/GV). GV, germinal vesicle; IVO, in vivo maturation.