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. 2022 Jun 2;2(5):100138. doi: 10.1016/j.xjidi.2022.100138

Figure 3.

Figure 3

Figure 3

ON101 alters the population of iNOS+, CD163+, and CD206+ cells in diabetic wound surroundings. Immunohistochemical staining of wound biopsies from db/db mice for detecting (a) iNOS, (c) CD163, and (e) CD206. (b) Quantification of iNOS-positive stain in the whole field compared with that in the total tissue area; n = 8 selected fields per group. (d) Quantification of the CD163-positive stain in the dermis compared with total nuclear stain. n = 16 selected fields per group. (e) Quantification of the CD206-positive stain in the wound edge compared with the nuclear stain in the field. n = 8 selected fields per group. All values represent means ± SEM. Statistical analysis is based on the Student's t-test. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.