Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 9;13:961599. doi: 10.3389/fimmu.2022.961599

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 McCallion, Nasirzadeh, Lingegowda, Miller, Khalaj, Ahn, Monsanto, Bidarimath, Sisnett, Craig, Young, Lessey, Koti and Tayade

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Significantly higher mast cell numbers and stem cell factor concentrations found in ectopic endometriotic tissue than eutopic endometrium. Activated Mast cells are increased in human endometriotic lesions compared to matched eutopic endometrium. Immunohistochemistry for mast cell tryptase in eutopic endometrial samples (A) and endometriotic lesions (B) from stage III-IV endometriosis patients (n=6). Quantitative analysis (C) revealed significantly higher number of mast cells/mm² in ectopic lesions compared to eutopic endometrium (p<0.01). Mast cell tryptase positive cells are indicated by black arrowheads. Scale bars: (A) 150µm, (B) 300µm, (C) 75µm, (D) 100µm. Stem cell factor concentration in human endometriotic lesions vs eutopic endometrium (n=15) (D), SCF concentrations in peritoneal fluid of endometriosis patients (n=14) stratified by disease stage (E).