Table 1.

Genes targeted in custom RT² Profiler PCR array.

Gene	Protein encoded	Function in mast cell biology	EMS lesion vs. normal	P value	EMS lesion vs. EMS eutopic	P value	EMS eutopic vs. normal	P value
IL1B	Interleukin 1-β	Recruitment	+	0.427	+	1.7E-5	+	0.162
IL3	Interleukin 3	Recruitment, differentiation	+	0.103	+	5E-10	+	0.44
VCAM1	Vascular adhesion protein 1	Recruitment	+	2.0E-6	/	0.5	+	0.533
CCL2	C-C Motif chemokine ligand 2	Recruitment	+	2.06E-4	+	4.97E-5	+	0.358
TAC1	Preprotachykinin-1 AKA “Substance P”	Differentiation	+	0.173	+	0.0049	+	0.253
CMA1	Mast cell chymase 1	Differentiation	+	0.0073	+	2.3E-8	+	0.0627
TPSAB1	Mast cell tryptase	Differentiation, activation	+	0.0053	+	1.86E-11	+	0.126
TNF	Tumor necrosis factor	Activation/function	+	0.0204	+	1.41E-7	+	0.452
KITLG	Stem cell factor (kit ligand; c-kit)	Differentiation, recruitment	+	0.0047	+	0.27	+	0.969
CCR1	C-C Motif chemokine receptor 1	Activation/function	+	0.0014	+	1.0E-15	+	0.0369
CPA3	Mast cell carboxypeptidase 3	Activation/function	+	1.32E-4	+	0.0525	+	0.251
GAPDH	Glyceraldehyde 3-phosphate dehydrogenase	Housekeeping gene	n/a	n/a	n/a	n/a	n/a	n/a
ACTB	β-actin	Housekeeping gene	n/a	n/a	n/a	n/a	n/a	n/a

“+”, significantly upregulated (fold change > 1.0; p<0.05), “+”, upregulated (fold change higher than 1.0), “-”, downregulated (fold change lower than -1.0), “/”, no observed difference (-1.0 < fold change < 1.0).