Table 2. Comparison of the performance among NFS, APRI, FIB-4, and BARD in the NHANES cohort.
| Cutoffs | AUROC | Accuracy (%) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | PLR | NLR | DOR | Youden’s index | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NFS | −1.455 | 42.5 | 84.8 | 35.9 | 17.2 | 93.8 | 1.32 | 0.42 | 3.14 | 0.207 | |
| 0.159 | 0.679 | 72.4 | 51.7 | 75.7 | 25.1 | 90.9 | 2.13 | 0.64 | 3.33 | 0.274 | |
| 0.676 | 79.1 | 37.6 | 85.6 | 29.1 | 89.7 | 2.62 | 0.73 | 3.59 | 0.233 | ||
| APRI | 0.3 | 0.616 | 77.6 | 36.5 | 84.0 | 26.4 | 89.4 | 2.29 | 0.76 | 3.01 | 0.205 |
| 0.5 | 85.2 | 14.3 | 96.3 | 37.8 | 87.7 | 3.86 | 0.89 | 4.34 | 0.106 | ||
| 1.5 | 86.6 | 2.3 | 99.9 | 80.0 | 86.7 | 25.46 | 0.98 | 25.98 | 0.022 | ||
| FIB-4 | 1.02 | 0.601 | 58.0 | 58.4 | 57.9 | 17.9 | 89.9 | 1.39 | 0.72 | 1.93 | 0.163 |
| 1.30 | 68.5 | 37.6 | 73.4 | 18.2 | 88.2 | 1.41 | 0.85 | 1.66 | 0.110 | ||
| 1.45 | 73.0 | 32.9 | 79.3 | 20.0 | 88.3 | 1.59 | 0.85 | 1.87 | 0.122 | ||
| 2.67 | 86.1 | 9.3 | 98.2 | 44.6 | 87.3 | 5.12 | 0.92 | 5.57 | 0.075 | ||
| 3.25 | 86.9 | 6.7 | 99.5 | 68.6 | 87.2 | 13.89 | 0.94 | 14.78 | 0.063 | ||
| BARD | 2 | 48.0 | 63.8 | 45.5 | 15.5 | 88.9 | 1.17 | 0.80 | 1.46 | 0.093 | |
| 3 | 0.589 | 79.8 | 29.2 | 87.7 | 27.2 | 88.7 | 2.37 | 0.81 | 2.93 | 0.169 |
Best cutoff value is presented in italic font. AUROC, area under the receiver operating characteristic curve; DOR, diagnostic odds ratio; NLR, negative likelihood ratio; NPV, negative predictive value; PLR, positive likelihood ratio; PPV, positive predictive value.