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. 2022 Jun 2;18(2):280–283. doi: 10.4103/1673-5374.346475

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Maternal programming by high-energy dense diets (CAF) primes defects in social behavior in the offspring.

(A) Subjects born from mothers exposed to CAF develop major interaction with the inanimate object when compared with subjects exposed to chow diet. (B) Accumulation of MCP-1 chemokine in offspring of dams exposed to CAF during programming. (C) MRI imaging of primary somatosensory cortex (SSP) or lobe X of cerebellum (CbX) comparing volumetric changes in the offspring of control and CAF subjects followed MCP-1 antibody inoculation. Adapted from Maldonado-Ruiz et al. (2021) with permission. A: Motivated; CAF: cafeteria; CON: control; NA: non-motivated. Created with BioRender.com.