Figure 3.

Microglia depletion in the second postnatal week leads to reduced sensory-driven activation of the cortical network

(A–C) Average firing rate (Hz) of L2/3, L4, and L5/6 at baseline, without any whisker stimulation.

(D–I) Average traces of MUA evoked by multi-whisker stimulation at low and high frequencies; the blue arrows indicate whisker deflection. “Total” and “late” area under the curves (AUCs) are measured as indicated in the STAR Methods.

Each dot is a mouse. CTRL n = 8, PLX n = 4; (A) t test p = 0.61; (B) t test p = 0.28; (C) t test p = 0.18; (D′) Wilcoxon test p = 0.004; (D′′) t test p = 0.064; (E′) t test p = 0.081; (E′′) t test p = 0.12; (F′) t test p = 0.027; (F′′) t test p = 0.12; (G′) t test p = 0.15; (G′′) t test p = 0.034; (H′) t test p = 0.44; (H′′) t test p = 0.5; (I′) Wilcoxon test p = 0.15; (I′′) Wilcoxon test p = 0.15. Representative examples of silicon probe recordings are reported in Figure S3.

All data are represented as mean ± SEM, and the exact values are reported in Table S1.