Table 1.
The IC50 (μM) ± S.E.[a] for Ag–NHC complexes 2a-i on L929, MCF-7, and SH-SY5Y cell lines and relative activity of Ag(I)–NHC complexes to cisplatin.
| Compound | L929 Cell Line | MCF-7 Cell Line | SH-SY5Y Cell Line |
|---|---|---|---|
| Cisplatin | 11.6 ± 0.5 | 7.2 ± 0.4 | 10.2 ± 0.4 |
| 2a | 63.48 ± 0.4 | 98.29 ± 1 | 23.60 ± 0.7 |
| 2b | 37.11 ± 0.9 | 20.67 ± 0.6 | 2.55 ± 0.7 |
| 2c | 53.53 ± 0.9 | 76.02 ± 0.4 | 8.86 ± 0.4 |
| 2d | 1.18 ± 0.3 | 2.66 ± 0.6 | 0.25 ± 0.8 |
| 2e | 155.9 ± 0.5 | 21.32 ± 1 | 71.17 ± 1 |
| 2f | 404.3 ± 0.7 | 35.63 ± 0.5 | 82.46 ± 0.6 |
| 2g | 18.71 ± 0.5 | 6.56 ± 0.6 | 13.74 ± 0.5 |
| 2h | 45.41 ± 1 | 16.33 ± 0.8 | 24.73 ± 0.9 |
| 2i | 140.7 ± 0.5 | 53.64 ± 0.6 | 88.89 ± 0.5 |
∗Values are mean value ±standard error of three different replicates.