Table 15.
Drug likeness assessment of the lead compounds based on Ghose, Veber, Egan, Muegge, QED, and Synthetic accessibility scores.
| Molecule | Ghose | Veber | Egan | Muegge | QED | SA score |
|---|---|---|---|---|---|---|
| 9 | Yes | No | No | No | 0.62 | 3.148 |
| 10 | Yes | No | No | No | 0.582 | 3.215 |
| 11 | Yes | No | No | No | 0.582 | 3.158 |
| 17 | Yes | No | No | No | 0.549 | 3.25 |
| 22 | Yes | No | No | No | 0.515 | 3.32 |
| 31 | Yes | No | No | No | 0.554 | 3.272 |
| Oseltamivir | Yes | Yes | Yes | Yes | 0.213 | 4.392 |
| Zanamivir | Yes | Yes | Yes | Yes | 0.691 | 3.758 |
Key: Quantitative Estimate of Drug-likeness (QED), Synthetic accessibility (SA) score.