Table 1.
Baseline and ICU Admission Characteristics.
| Hematological malignancy (n = 10,401) | Solid malignancy (n = 35,920) | Without malignancy (n = 423,984) | ||
|---|---|---|---|---|
| Age (years) | 63.9 (13.9) | 67.5 (12.0) | 62.3 (17.3) | |
| Gender (male) | 6495 (62.5%) | 20,805 (57.9%) | 238,323 (56.2%) | |
| BMI | 25.2 (4.8) | 25.8 (5.1) | 26.4 (5.9) | |
| APACHE IV score | 86 [68-109] | 59 [43-81] | 57 [38-81] | |
| Comorbidity | ||||
| COPD and respiratory insufficiency | 1405 (13.9%) | 5687 (15.8%) | 75,214 (17.7%) | |
| Renal insufficiency and dialysis | 858 (8.2%) | 1651 (4.6%) | 27,699 (6.5%) | |
| Liver cirrhosis | 110 (1.1%) | 337 (0.9%) | 7806 (1.8%) | |
| Cardiovascular insufficiency | 328 (3.2%) | 1050 (2.9%) | 21,645 (5.1%) | |
| Immunological insufficiency | 6210 (59.7%) | 6121 (17.0%) | 23,621 (5.6%) | |
| Underlying type hematological malignancy | ||||
| Leukemia | 1342 (12.9%) | |||
| Hodgkin lymphoma | 118 (1.1%) | |||
| Non-Hodgkin lymphoma | 813 (7.8%) | |||
| Bone marrow transplant | 57 (0.5%) | |||
| Hematological malignancy, not specified | 8071 (77.6%) | |||
| Specification cohort 1 | ||||
| Comorbidity: hematological malignancy | 6599 (63.4%) | |||
| Referral specialism: hematology | 284 (2.7%) | |||
| Both comorbidity and referral specialism | 802 (7.7%) | |||
| APACHE IV diagnosis: hematological malignancy | 2330 (22.4%) | |||
| APACHE IV diagnosis: other | 386 (3.7%) | |||
| Underlying type solid malignancy | ||||
| Gastrointestinal malignancy | 11,037 (30.7%) | |||
| Pancreas malignancy | 842 (2.3%) | |||
| Renal/urogenital malignancy | 2985 (8.3%) | |||
| Neurological malignancy | 2144 (6.0%) | |||
| Respiratory malignancy | 4696 (13.1%) | |||
| Solid malignancy, not specified | 14,216 (39.6%) | |||
| Specification cohort 2 | ||||
| Comorbidity: neoplasm | 13,211 (36.8%) | |||
| Referral specialism: oncology | 183 (0.5%) | |||
| Both comorbidity and referral specialism | 344 (1.0%) | |||
| APACHE IV diagnosis: solid malignancy | 21,704 (60.4%) | |||
| APACHE IV diagnosis: other | 478 (1.3%) | |||
| Admission reason | ||||
| Respiratory failure | 1038 (10.5%) | 2062 (9.8%) | 33,287 (7.9%) | |
| Sepsis | 2454 (24.9%) | 3484 (16.6%) | 38,235 (9.0%) | |
| Pneumonia | 2427 (24.6%) | 2323 (11.0%) | 40,097 (9.5%) | |
| Acute kidney injury/failure | 163 (1.7%) | 313 (1.5%) | 4408 (1.0%) | |
| Complications of surgery | 49 (0.5%) | 730 (3.5%) | 7375 (1.7%) | |
| Cardiac disease | 582 (5.9%) | 1289 (6.1%) | 36,370 (8.6%) | |
| Cardiac arrest | 351 (3.6%) | 849 (4.0%) | 27,074 (6.4%) | |
| Neurological | 465 (4.7%) | 1213 (5.8%) | 38,350 (9.0%) | |
| Medication related | 17 (0.2%) | 81 (0.4%) | 15,493 (3.7%) | |
| Gastrointestinal | 885 (9.0%) | 4388 (20.9%) | 47,987 (11.3%) | |
| Metabolic/endocrine | 176 (1.8%) | 578 (2.7%) | 11,362 (2.8%) | |
| Thromboembolism | 146 (1.5%) | 612 (2.9%) | 11,548 (2.7%) | |
| Other | 1111 (11.3%) | 3078 (14.6%) | 111,798 (26.4%) | |
| Admission type | ||||
| Medical | 9212 (88.7%) | 13,540 (38.0%) | 296997 (71.4%) | |
| Emergency surgery | 888 (8.6%) | 7435 (20.9%) | 81295 (19.5%) | |
| Elective surgery | 280 (2.7%) | 14,624 (41.1%) | 37707 (9.1%) | |
| Admitted from | ||||
| Emergency department | 2243 (21.9%) | 4286 (12.1%) | 150,865 (36.6%) | |
| Operation theatre | 1019 (10.0%) | 19,353 (54.5%) | 101,675 (24.6%) | |
| Ward | 6101 (59.6%) | 10,203 (28.7%) | 122,253 (29.6%) | |
| CCU/ICU | 678 (6.6%) | 950 (2.7%) | 25,342 (6.1%) | |
| Special/medium care | 64 (0.6%) | 299 (0.8%) | 2748 (0.7%) | |
| Home | 78 (0.8%) | 191 (0.5%) | 5469 (1.3%) | |
| Other | 49 (0.5%) | 231 (0.7%) | 4409 (1.1%) | |
| Diagnoses at admission | ||||
| CPR | 476 (4.6%) | 1130 (3.1%) | 30,616 (7.2%) | |
| Gastrointestinal bleeding | 365 (3.5%) | 1105 (3.1%) | 12,960 (3.1%) | |
| Cardiovascular | 1461 (14.1%) | 3290 (9.2%) | 57,336 (13.5%) | |
| Neurological | 368 (3.5%) | 1950 (5.4%) | 12,960 (3.1%) | |
| Diabetes | 1318 (12.7%) | 5103 (14.2%) | 68,826 (16.2%) | |
| Diagnoses within 24 h of ICU admission | ||||
| Acute renal failure | 2155 (20.7%) | 3663 (10.2%) | 47,142 (11.1%) | |
| Mechanical ventilation | 5236 (50.3%) | 13,105 (36.5%) | 19,2411 (45.4%) | |
| Confirmed infection | 4116 (39.6%) | 6639 (18.5%) | 83,919 (19.8%) | |
| Vasoactive drugs | 4913 (47.2%) | 13,186 (36.7%) | 146,767 (34.6%) | |
Data are displayed as mean (standard deviation) for continuous and count (percentages) for categorical variables, all P values was highly significant with a P < 0.01.
Abbreviations: APACHE, Acute Physiology and Chronic Health Evaluation; BMI, body mass index; CCU, coronary care unit; CPR, cardiopulmonary resuscitation; COPD, chronic obstructive pulmonary disorder; ICU, intensive care unit.