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. 2022 Aug 23;19:39. doi: 10.1186/s12979-022-00296-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Vaccine antibody responses against A/H1N1, A/H3N2 and B are associated with biological aging in high-dose recipients. A The geometric mean titres in standard-dose (SD) and high-dose (HD) recipients pre-vaccination (ie. 0) and 4-, 10- and 20-weeks post-vaccination in older adults stratified by degree of biological aging; significance of trend test indicated by X (negative association) or # (positive association). B Standardized coefficients and 95% confidence intervals for the association between the natural-log 4-week titre and BA, adjusted for the fixed effect of baseline titre and other covariates; lack of overlap with the red dotted line indicates significance