| Gene knockdown via RNA interference can be induced by small interfering RNAs and opens novel avenues towards innovative therapies in many diseases. |
| Despite their very attractive mechanism of action, the development of small interfering RNA therapeutics faces several challenges and issues. |
| Two decades after the discovery of the RNA interference mechanism, the first small interfering RNA drugs have received approval for clinical use and several other small interfering RNAs are in late-stage clinical studies. |
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