Table 1.
Summary of clinical trials involving exosomes in ALI/ARDS patients.
| Nct Number | Study Title | Number Enrolled | Status | Locations | Study Completion | Phase | Exosome Sources | Study Type | |||
| NCT04602104 | A Clinical Study of Mesenchymal Stem Cell Exosomes Nebulizer for the Treatment of ARDS | 169 | Recruiting | Ruijin Hospital, Medical School of Shanghai Jiaotong University Shanghai, Shanghai, China | September, 2022 | 1,2 | human mesenchymal stem cell- exosomes | Interventional | |||
| NCT04798716 | The Use of Exosomes for the Treatment of Acute Respiratory Distress Syndrome or Novel Coronavirus Pneumonia Caused by COVID-19 | 55 | Not yet recruiting | Mission Community Hospital Panorama City, California, United States | December, 2024 | 1,2 | Mesenchymal stem cell- exosomes | Interventional | |||
| NCT04747574 | Evaluation of the Safety of CD24- Exosomes in Patients With COVID-19 Infection | 35 | Completed | Tel Aviv Medical Center Tel Aviv, Israel | Marth 25th, 2021 | 1 | CD24- exosomes | Interventional | |||
| NCT04493242 | Extracellular Vesicle Infusion Treatment for COVID-19 Associated ARDS | 120 | Completed | Helen Keller Hospital Sheffield, Alabama, United States St. Joseph Hospital Heritage Fullerton, California, United States Donald Guthrie Foundation/ Robert Packer Hospital Sayre, Pennsylvania, United States | May 22nd, 2021 | 2 | Bone marrow mesenchymal stem cell EXO-FLO | Interventional | |||
| NCT05127122 | Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles | 81 | Not yet recruiting | Not mentioned | August, 2022 | 1,2 | Bone marrow mesenchymal stem cell EXO-FLO | Interventional | |||
| NCT04657458 | Infusion Treatment Expanded Access Protocol on Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicle Infusion Treatment for Patients With COVID-19 Associated ARDS | Not mentioned | Avaliable | Not mentioned | Not mentioned | 2 | Bone marrow mesenchymal stem cell EXO-FLO | Expand Access | |||
| NCT04969172 | A Phase II Randomized, Double-blind, Placebo- controlled Study to Evaluate the Safety and Efficacy of Exosomes Overexpressing CD24 to Prevent Clinical Deterioration in Patients With Moderate or Severe COVID-19 Infection | 155 | Active, not recruiting | Tel-Aviv Sourasky Medical Center Tel-Aviv, Israel | July 11th, 2022 | 2 | Exosomes overexpressing CD24 | Interventional | |||
| NCT04276987 | A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia | 24 | Completed | Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai, Shanghai, China | July 31st, 2021 | 1 | MSC-derived exosomes | Interventional | |||