Table 4.

Summary of lipidomics-derived pathways

Lipid class	Pathway	Lipid	Gene	Direction	p value/fold change
Sterol	Steroid biosynthesis	24,25-Dihydrolanosterol		Decreased	0.0056
		Lanosterol		Decreased	< 0.0001
		14-Demethyl-lanosterol		Decreased	0.0004
		Zymosterol		Decreased	0.0001
		Zymostenol		Decreased	0.0106
	Primary bile acid biosynthesis	25-Hydroxycholesterol		Increased	< 0.0001
		7alpha-Hydroxycholesterol		Decreased	0.0025
		7alpha-hydroxy-4-cholesten-3-one		Decreased	0.0013
Free fatty acid	Biosynthesis of unsaturated fatty acids	20:5 (Eicosapentaenoic acid)		Increased	< 0.0001
		22:5 (Docosapentaenoic acid)		Increased	< 0.0001
		22:6 (Docosahexaenoic acid)		Increased	0.0001
		20:3 N9 (Eicosatrienoic acid)		Decreased	0.0037
		20:4 (Arachidonic acid)		Increased	< 0.0001
		22:4 (Adrenic acid)		Increased	< 0.0001
		20:1 (Icosenoic acid)		Decreased	0.0199
	Linoleic acid metabolism	20:4 (Arachidonic acid)		Increased	< 0.0001
		20:3 N9 (Eicosatrienoic acid)		Decreased	0.0037
			PLA2G4A	Decreased	– 8.14
Phospholipid	Glycerophospholipid metabolism	Phosphatidylglycerol		Increased	0.0189
		Phosphatidylserine		Increased	0.0072
			PLA2G4A	Decreased	– 8.14
			GPAT4	Decreased	–10.64
Acylcarnitine	Fatty acid degradation	CAR 16:0 (L-palmitoylcarnitine)		Increased	0.0004

p values are shown for lipids and fold changes are shown for genes