Table 3.
Mediators involved in enzymatic degradation reactions during LDH reabsorption
| Regulator | Sample | Results | Reference |
|---|---|---|---|
| MMP-1, MMP-3 | Human IVD | Compared with MMP-1, MMP-3 is more conducive to LDH reabsorption. | Genevay et al. 2009 [101] |
| MMP-1, MMP-3 | Human IVD | MMP-3 promotes degeneration of cartilage endplates. | Kanemoto et al. 1996 [102] |
| MMP-3, MMP-7, MMP-8 | Human IVD | MMP-3, MMP-7, and MMP-8 play a role in nucleus pulposus reabsorption. | Haro et al. 1999 [103] |
| rhMMP3, rhMMP7 | Human/rabbit/dog IVD | rhMMP-7 promotes LDH reabsorption. | Haro et al. 2005 [66] |
| MMP-1, MMP-3 | Human IVD | The expression of MMP-1 and MMP-3 is increased in inflammatory cells of IVD granulation tissue. | Matsui et al. 1998 [104] |
| MMP-1, MMP-3 | Co-culture of human IVD and monocytes | Cytokine stimulation helps promote the production of matrix metalloproteinases in intervertebral disc cells. | Doita et al. 2001 [105] |
| MMP-3, MMP-7, TNF-α | Co-culture system of mouse IVD and macrophages | MMP-7 produced by macrophages is required for proteoglycan degradation and macrophage infiltration. | Haro et al. 2000 [106] |
Abbreviations: rhMMP recombinant human matrix metalloproteinase