Table 2.
Neuroimaging markers of SVD between As-CMI and Larger RSSI groups
|
As-CMI, n = 23 |
Larger RSSI, n = 561 |
Fully-adjusted* OR(95%CI) |
P value | |
|---|---|---|---|---|
| Presence of Lacunes | 14(60.9) | 188(33.5) | 2.88(1.21–6.84) | 0.016 |
| Lacunes number | 0.039 | |||
| 0 | 9(39.1) | 373(66.5) | Reference | |
| 1 | 6(26.1) | 102(18.2) | 2.34(0.81–6.79) | 0.115 |
| > 1 | 8(34.8) | 86(15.3) | 3.50(1.29–9.48) | 0.013 |
| The severity of WMH | 0.060 | |||
| 0–2 | 11(47.8) | 310(55.3) | Reference | |
| 3–4 | 3(13.0) | 154(27.5) | 0.52(0.14–1.90) | 0.323 |
| 5–6 | 9(39.1) | 97(17.3) | 2.29(0.90–5.80) | 0.081 |
| The severity of EPVS in BG | 0.391 | |||
| ≤ 10 | 5(21.7) | 227(40.5) | Reference | |
| 11–20 | 13(56.5) | 220(39.2) | 2.07(0.68–6.28) | 0.198 |
| > 20 | 5(21.7)) | 114(20.3) | 1.38(0.34–5.59) | 0.645 |
| The severity of EPVS in CSO | 0.559 | |||
| ≤ 10 | 4(17.4) | 76(13.5) | Reference | |
| 11–20 | 10(43.5) | 287(51.2) | 0.51(0.14–1.75) | 0.285 |
| > 20 | 9(39.1) | 198(35.3) | 0.56(0.15–2.05) | 0.383 |
| Total CVSD Burden | 2(1–3) | 1 (0–2) | 1.68(1.11–2.53) | 0.013 |
Abbreviation: SVD, Cerebral small vessel disease; WMH, White matter hyperintensity; EPVS, Enlarged perivascular spaces; BG, Basal ganglia, CSO, Centrum semiovale
*Adjusted for age, sex, coronary artery disease