Table I.
Analysis of trabecular bone properties in the femur of mice fed vitamin D-sufficient or vitamin D-deficient diet, and treated with ß-caryophyllene or mock-treated (control).
| Property | Group | p-values | ||||||
|---|---|---|---|---|---|---|---|---|
| D- control | D- BCP | D+ control | D+ BCP | D- control vs D- BCP | D+ control vs D+ BCP | D- control vs D+ control | D- BCP vs D+ BCP | |
| Mean VOX-TV, mm3 (SD) | 1.42 (0.08) | 1.44 (0.08) | 1.29 (0.04) | 1.32 (0.10) | 0.632 | 0.395 | 0.000 | 0.007 |
| Mean VOX-BV, mm3 (SD) | 0.13 (0.05) | 0.19 (0.09) | 0.05 (0.01) | 0.09 (0.03) | 0.054 | 0.002 | 0.001 | 0.004 |
| Mean VOX-BV/TV, % (SD) | 0.09 (0.03) | 0.13 (0.06) | 0.04 (0.01) | 0.06 (0.02) | 0.050 | 0.001 | 0.001 | 0.004 |
| Mean Conn-Dens., mm2 (SD) | 26.96 (16.30) | 51.86 (34.29) | 9.03 (5.29) | 18.92 (10.49) | 0.059 | 0.019 | 0.007 | 0.015 |
| Mean TRI-SMI (SD) | 3.08 (0.29) | 2.76 (0.43) | 3.32 (0.19) | 3.05 (0.20) | 0.067 | 0.006 | 0.047 | 0.079 |
| Mean DT-Tb.N, 1 /mm (SD) | 3.59 (0.47) | 4.07 (0.71) | 2.76 (0.36) | 3.13 (0.29) | 0.095 | 0.022 | 0.000 | 0.002 |
| Mean DT-Tb.Th, μm (SD) | 0.06 (0.01) | 0.07 (0.00) | 0.05 (0.00) | 0.06 (0.01) | 0.216 | 0.001 | 0.000 | 0.012 |
| Mean DT-Tb.Sp, μm (SD) | 0.28 (0.03) | 0.25 (0.04) | 0.37 (0.06) | 0.32 (0.03) | 0.071 | 0.042 | 0.001 | 0.000 |
| Mean apparent density, g/cm3 (SD) | 114.78 (23.45) | 145.24 (32.69) | 76.00 (10.62) | 98.08 (12.62) | 0.029 | 0.001 | 0.000 | 0.001 |
| Mean material density, g/cm3 (SD) | 528.62 (23.67) | 531.77 (25.80) | 499.67 (30.15) | 518.23 (17.37) | 0.779 | 0.113 | 0.029 | 0.188 |
| Mean TRI-TV, mm3 (SD) | 1.41 (0.08) | 1.42 (0.08) | 1.27 (0.04) | 1.30 (0.10) | 0.631 | 0.399 | 0.000 | 0.007 |
| Mean TRI-BV, mm3 (SD) | 0.12 (0.05) | 0.19 (0.09) | 0.04 (0.01) | 0.08 (0.03) | 0.055 | 0.002 | 0.001 | 0.004 |
| Mean TRI-BV/TV (SD) | 0.09 (0.03) | 0.13 (0.06) | 0.03 (0.01) | 0.06 (0.02) | 0.050 | 0.001 | 0.001 | 0.004 |
| Mean TRI-BS, mm2 (SD) | 5.72 (1.67) | 8.15 (2.94) | 2.64 (0.62) | 4.18 (1.20) | 0.039 | 0.003 | 0.000 | 0.002 |
| Mean TRI-BS/BV (SD) | 48.87 (5.32) | 45.45 (4.78) | 60.75 (5.99) | 51.57 (5.35) | 0.148 | 0.002 | 0.000 | 0.015 |
| Mean TRI-Tb.N, 1 /mm (SD) | 2.03 (0.57) | 2.84 (0.94) | 1.04 (0.25) | 1.59 (0.38) | 0.034 | 0.002 | 0.000 | 0.002 |
| Mean TRI-Tb.Th, μm (SD) | 0.04 (0.00) | 0.04 (0.00) | 0.03 (0.00) | 0.04 (0.00) | 0.160 | 0.002 | 0.000 | 0.015 |
| Mean TRI-Tb.Sp, μm (SD) | 0.49 (0.15) | 0.34 (0.11) | 0.98 (0.24) | 0.62 (0.14) | 0.020 | 0.001 | 0.000 | 0.000 |
| Mean TRI-DA (SD) | 1.46 (0.07) | 1.49 (0.05) | 1.48 (0.17) | 1.46 (0.11) | 0.190 | 0.870 | 0.737 | 0.494 |
BMD, bone mineral density; BS, bone surface; BV, bone volume; BV/TV, trabecular bone volume; Conn-Dens, connectivity density; DA, degree of anisotropy; DT, distance transformation; SD, standard deviation; SMI, structure model index; (Tb.N), trabecular number; (Tb.Sp), trabecular separation; (Tb.Th), trabecular thickness; TRI, triangularization of surface; VOX, voxels.