Table 3.

Univariate and multivariable logistic regression models for metabolic activity and a pathologic complete response (0% residual cancer)

Clinical feature		Univariable		Multivariable with SUV		Multivariable with TLG
		Odds ratio (95% CI)	p value	Odds ratio (95% CI)	p value	Odds ratio (95% CI)	p value
Agea		0.97 (0.92 – 1.03)	0.33
Sex	Male	1 (reference)	0.21
	Female	0.25 (0.02 – 2.17)
Location of tumor	Siewert type III	1 (reference)	0.45
	Stomach	0.59 (0.15 – 2.35)
Tumor differentiation Well/moderate		1 (reference)	0.48
	poorly	0.60 (0.15 – 2.46)
Lauren classification	Intestinal	1 (reference)	0.30
	Diffuse	0.49 (0.12 – 1.92)
Signet ring cells	YES	1 (reference)	0.04	1 (reference)	0.11	1 (reference)	0.13
	No	9.37 (1.10 –79.71)		6.44 (0.68 – 61.46)		5.62 (0.59 – 43.73)
Baseline T category	T1/2	1 (reference)	0.85
	T3/T4	0.80 (0.08 – 8.02)
Baseline N category	N0	1 (reference)	0.39
	N1/2/3	1.90 (0.44 – 8.23)
Baseline clinical stage	I/IIA/IIB	1 (reference)	0.45
	III/IVA	1.75 (0.40 – 7.58)
Primary SUVmax	<13.4	1 (reference)	0.001	1 (reference)	0.004
	≥13.4	14.28 (2.94 – 50.0)		11.1(2.12 – 50.0)
Primary TLG	<156	1 (reference)	0.02			1 (reference)	0.14
	≥156	5.88 (1.32 – 25.0)				3.33 (0.67 – 16.7)

SUV_max, maximum standardized uptake value; TLG, total lesion glycolysis; CI, confidence interval.

^aContinuous variable.