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The palatal phenotypes of FGFR2 S252W and P253R Apert mouse models. (A,B) Incomplete closure of the anterior Fgfr2+/2S252W secondary palate at P1 (B) compared to WT (A) (adapted from [84] and used with permission from Development: dev.biologists.org). (C,D) Incomplete closure of the anterior Fgfr2+/P253R secondary palate at P0 (D) compared to WT (C) (adapted from [85]). ns, nasal septum; sp, secondary palate. Arrows indicate incomplete fusion.
