Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic models of current targeted protein degradation (TPD) platforms that target a protein of interest (POI). Intracellular TPD platforms include (a) the proteasome-based PROTAC, (b) transmembrane E3 ligase-targeting antibody-based AbTAC, (c) lysosomal-targeting receptor-based LYTAC, (d) S-guanylation/autophagy-based AUTAC, (e) LC3/autophagy-based ATTEC, and (f) SQSTM1/autophagy-based AUTOTAC.
