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. 2022 Aug 18;60(1):1616–1624. doi: 10.1080/13880209.2022.2110127

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Concentrations of DOX and DOXol in the serum, heart, liver, and kidneys of mice treated with DOX alone or combined with ADI. DOX (A) and DOXol (B) concentrations in mice serum. DOX (C) and DOXol (D) concentrations in heart. DOX (E) and DOXol (F) concentrations in liver. DOX (G) and DOXol (H) concentrations in kidneys. Values are presented as mean ± SD (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 vs. single-dose administration of DOX; ^##P < 0.01, ^###P < 0.001 vs. multiple-dose administration of DOX.