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Time-concentration curves of DOX (A) and DOXol (B) in H9c2 cells. H9c2 cells were incubated with 5 μM DOX in the absence or presence of 1, 4, or 10% ADI for 1, 2, 4, 8, 12 and 18 h. DOX and DOXol concentrations in cells were quantified by UPLC-MS/MS. Data are expressed as mean ± SD of six independent experiments. **P < 0.01, ***P < 0.001 vs. DOX group at the same time.
