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. 2022 Aug 18;14(1):2112882. doi: 10.1080/19490976.2022.2112882

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Microbiota dysbiosis was worsened in mice of intestinal TLR4 deletion.

(a) Principle coordination analysis (PCoA) based on OTU abundance. (b) α-diversity analysis between four groups using Shannon index. (c) Cladograms generated by LEfSe showed the differences in taxa among four groups (from phylum to genus levels). (d) The taxonomic composition distribution among four groups on phylum-level of fecal microbiota. (e) The taxonomic composition distribution among four groups on genus-level of fecal microbiota. (f) The ratio of Firmicutes/Bacteroidetes among four groups were shown (phylum-level). (g) Relative abundance of norank_f_Muribaculaceae, g_Lactobacillus, unclassified_f_Lachnospiraceae and g_Mucispirillum were shown (genus-level). Data are provided as the mean ± SEM (n = 6 per group). *means p< .05 vs WT, #means p< .05 vs AP.