Table 1.
Demographics of the patient cohorts undergoing CyTOF and single-cell RNA-seq (scRNA-seq) analysis of peripheral blood.
| Healthy Controls No ICI |
Group A ICI + No irAE |
Group B ICI + Non-Myocarditis irAE |
Group C ICI + Myocarditis |
Total | |
|---|---|---|---|---|---|
| Group Size n | 23 (6) | 8 (8) | 13 (8) | 8 (8) | 52 (30) |
| Age in Mean Yrs | 71 (45) | 66 (67) | 64 (60) | 71 (72) | 67 (62) |
| Gender | M: n=17 (n=4) | M: n=6 (n=6) | M: n=10 (n=7) | M: n=7 (n=5) | M: n=40 (n=22) |
| F: n=6 (n=2) | F: n=2 (n=2) | F: n=3 (n=1) | F: n=1 (n=3) | F: n=12 (n=8) | |
| Malignancy | |||||
| Thoracic | 0 (0) | 1 (1) | 4 (2) | 4 (3) | 9 (5) |
| Melanoma | 0 (0) | 2 (2) | 4 (2) | 1 (1) | 7 (5) |
| Head/Neck | 0 (0) | 1 (1) | 1 (1) | 0 (1) | 2 (3) |
| Esophagogastric | 0 (0) | 0 (0) | 1 (1) | 0 (1) | 1 (2) |
| Lymphoma | 0 (0) | 0 (0) | 0 (0) | 1 (1) | 1 (1) |
| Genitourinary | 0 (0) | 4 (4) | 3 (2) | 2 (1) | 10 (7) |
| Recent Immunotherapy | |||||
| PD-1 | 0 (0) | 7 (7) | 11 (7) | 4 (5) | 22 (19) |
| PD-L1 | 0 (0) | 1 (1) | 1 (1) | 2 (1) | 4 (3) |
| PD-1 + CTLA-4 | 0 (0) | 0 (0) | 1 (0) | 2 (2) | 3 (2) |
| Diagnosis | |||||
| Healthy | 23 (6) | 8 (8) | 0 (0) | 0 (0) | 31 (14) |
| Thyroiditis | 0 (0) | 0 (0) | 3 (1) | 0 (0) | 3 (1) |
| Hypophysitis | 0 (0) | 0 (0) | 0 (1) | 0 (0) | 0 (1) |
| Hepatotoxicity | 0 (0) | 0 (0) | 4 (1) | 0 (0) | 4 (1) |
| Vitiligo | 0 (0) | 0 (0) | 1 (2) | 0 (0) | 1 (2) |
| Colitis | 0 (0) | 0 (0) | 3 (1) | 0 (0) | 3 (1) |
| Pneumonitis | 0 (0) | 0 (0) | 2 (1) | 0 (0) | 2 (1) |
| Pericarditis | 0 (0) | 0 (0) | 2 (1) | 0 (0) | 2 (1) |
| Myocarditis | 0 (0) | 0 (0) | 0 (0) | 8 (8) | 8 (8) |
Numbers outside of the parenthesis pertain to patient samples in which CyTOF was performed. Numbers in italics and in parenthesis pertain to patient samples in which scRNA-seq was performed.