Table 1.

Cytochrome oxidase (COX) deficiency (%) in different hindlimb skeletal muscles

	12 months		18 months		24 months
Muscle	Control	K320E‐Twinkleskm	Control	K320E‐Twinkleskm	Control	K320E‐Twinkleskm	P value
Soleus	0	0.15 ± 0.06	0	1.4 ± 1.02	0	4.36 ± 0.59	<0.0001
GAS	0	0.46 ± 0.25	0	5 ± 3	0	17.08 ± 3.23	<0.0001
TA	0	0.2 ± 0.07	0	1.18 ± 0.24	0	13.58 ± 1.22	<0.0001
EDL	0	0.12 ± 0.06	0	0.13 ± 0.05	0	3.03 ± 1.1	<0.0001

All values are mean ± SEM.